
End stage renal disease (GFR 6-17 years: 5 mg once daily recommended not to exceed 20 mg once daily for children 6 to 12 years of age.12 years: 10 mg/day PO initially may increase by 10 mg/day qWeek not to exceed 60 mg given qDay or divided doses with intervals of 4-6 hr between doses Dosing Modifications Severe renal impairment.6 years: 5 mg PO qDay or q12hr may increase by 5 mg qWeek not to exceed 40 mg qDay or divided q8hr use intervals of 4-6 hr between additional doses.ESRD (GFR

Severe renal impairment (GFR 15 to No more than 60 mg given qDay or divided doses with intervals of 4-6 hr between doses.5-60 mg PO qDay may increase by 10 mg/day qWeek.Note: 25 mg qAM may be considered as an initial dose for some patients.May increase by increments of 12.5 mg/week not to exceed 50 mg/day.

